I actually only bought RE4 for the first time a few weeks ago. I had previously rented it and beaten it on the second time, but I had to OWN it, you know?
So anyway, I'm playing through Pro mode and having a fuck of a time (thanks in part to the Halo 2 soundtrack, which fits the game, like, really well), but then I get to the part where you're trapped in the cabin with Luis and a bunch of jerks are coming in through the windows, and you basically just have to survive until they fuck off, and I totally keep getting my ass handed to me. I'm usually fine until I go upstairs to lure them onto the staircase so I can grenade all of them to pieces, and after that they bust out the ladders and overwhelm me.