Okay, the bass players have their own thread, so it's only fair that there's a thread for those of us with the dexterity to handle six strings instead of four or five.
My number one guitar: THE CULPRIT
The pickups are basically high gain melt-your-face-off-and-don't-talk-to-me-about-tone-quality, but they do the high gain thing damn well, and for an instrument that only set me back $600 used, it's got great action and hardware. It'll really be a mean axe once I get some Seymour Duncans for it.
What I really want is a custom neck-thru PRS. I played a couple of store models at Guitar Center last time I was there, and they beat every other guitar I've seen in terms of playability.